Significance of HPV Infection and Genic Mutation of APC and K-ras for Rectal Cancer

Colorectal cancer is one of the most common malignancies, but its pathogenesis hasn’t been elucidate so far. Recently, most researchers consider that occurrence and evolution of colorectal cancer refer to mutiple factors, more procedures and complex sequential change of polygenes in different segments. Meanwhile, In different regions virus infection involved in it, of which human papilloma virus (HPV) has occupied the most for being researched (Cimino-Mathews et al., 2012), while its detection positive incidence exists more difference (Kirgan et al., 1990; Zhou et al., 2004; Yavuzer et al., 2010). And gene oncogene APC and P53 have been researched most,